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Advanced Imaging for Glaucoma

Casey Eye Institute, OHSU

3375 Southwest Terwilliger Boulevard

Portland, OR 97239-4197


Phone: 503-494-5131



Welcome to the AIG Study Website

Advanced Imaging for Glaucoma (AIG) is a multi-center bioengineering partnership sponsored by the National Eye Institute, one of the National Institutes of Health (NIH).


The goal of this partnership is to develop advanced imaging technologies that can improve the detection and management of glaucoma. Currently-employed advanced imaging devices include optical coherence tomography, scanning laser polarimetry and scanning laser tomography. The imaging technologies will be evaluated in a longitudinal 5-year clinical trial. The study subjects will include patients with normal eyes, patients with glaucoma, and individuals at risk for developing glaucoma.


ANNOUNCEMENTS - AIGS comes to an end


The Advanced Imaging for Glaucoma Study officially ended on August 31, 2013. As principal investigator, Dr. Huang would like to thank the participants for their commitment to the project.


With your participation, we were able to evaluate and compare the diagnostic accuracy of the eye measurements made by various imaging technologies. We learned that diagnosis could be improved by combining measurements from different parts of the eyes that were affected by glaucoma the optic disc, nerve fiber layer, and macular ganglion cell complex. And we found that these imaging results could help predict the development of glaucoma and its subsequent progression.


September 2013 - Letter from Dr. David Huang to AIGS Study Participants


Clinical centers:

University of Miami, Bascom Palmer Eye Institute, Miami, Florida
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
University of Southern California, Doheny Eye Institute, Los Angeles, California
Oregon Health & Science University, Casey Eye Institute, Portland, Oregon

Basic science and engineering centers:

Oregon Health & Science University, Casey Eye Institute, Portland, Oregon
Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science and Research Lab of Electronics, Boston, Massachusetts

Resource center:

Cleveland Clinic Foundation, Cleveland, Ohio

Specific Aims

The specific aims of the AIG clinical studies are to:


1. Predict the development of visual field (VF) abnormalities in individuals at risk for developing glaucoma based on anatomic abnormalities detected by advanced imaging;

2. Predict the development of VF abnormalities in individuals at risk for developing glaucoma based on anatomic changes detected between successive advanced imaging tests; and

3. Determine the sensitivity and specificity of a glaucoma diagnosis based on advanced imaging tests.



The coordinating center for the AIG partnership is located at the Oregon Health & Science Unversity (OHSU). There are a total of four centers that will be conducting the AIG clinical study, two basic science and engineering centers that will develop the advanced imaging instruments and conduct laboratory studies on glaucoma and one resource center.


July 7, 2011

OHSU Clinical Center began accepting AIGS study subjects as of July 18, 2011!